Isoelectric focusing combined with immunoblotting requires smaller CSF volume and is more sensitive due to higher resolution peaks, which are easily discriminated from the background. A variety of experimental techniques have been used to detect the presence of OCB in the CSF, including agarose gel electrophoresis (AGE) and isoelectric focusing combined with immunoblotting (IEF-IB). Nevertheless, abnormal CSF analysis is not required to establish the diagnosis of clinically definite MS based on McDonald criteria, though the expert panel reaffirmed the significance of abnormal CSF findings in supporting the diagnosis of MS and evaluating alternate diagnosis. Moreover, CSF-OCB positive patients have been associated with a more rapid conversion from clinically isolated syndrome (CIS) to clinically definite MS. However, due to its high diagnostic sensitivity in MS, as well as its high specificity in the appropriate clinical setting, examination of CSF-OCB particularly in the evaluation of patients with early or atypical MS is strongly recommended. Oligoclonal bands have been reported in other primary and secondary CNS immune-mediated disorders (CIMD) that may clinically mimic MS such as CNS lupus, various forms of CNS vasculitis, neurosarcoidosis, antiphospholipid syndrome, CNS infections, CNS lymphoma and neuromyelitis optica spectrum disorder (NMOSD). Although CSF-OCB is present in approximately 90–95% of MS patients, they are not unique to MS. The Diagnosis of MS is based on the McDonald criteria entailing dissemination in time and space as demonstrated by clinical and magnetic resonance imaging (MRI) findings. Central nervous system (CNS) inflammation in MS is associated with intrathecal production of immunoglobulins (IgG) derived from plasma cells, which represent a restricted set of B cell clones and confirmed by the presence of oligoclonal bands (OCB) in the cerebrospinal fluid (CSF). This reliable review book contains everything needed to successfully prepare for board exams or recertification exams in neurology.Multiple Sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) that is most commonly diagnosed between 20 and 40 years of age. A new appendix, "Tight Association List," enables readers to recognize commonly associated clinical terms in a multiple-choice setting.Filled with efficient summary tables and boxedĬontent to highlight the most salient "take-aways".Full-color, detailed illustrations and pathology.Content reflects the core continuing medicalĮducation topics established by the American Academy of Neurology.Updates included in this second edition include a section on coma, expanded coverage of epilepsy, an overview of new pharmacological treatments for multiple sclerosis, and much more! Written in a concise outlineįormat, the text distills all the information typically needed to master the Neurologists preparing for recertification exams.
Of Psychiatry and Neurology (ABPN) board examination. Studying for the Resident In-Service Training Exam (RITE) and the American Board Doody’sĬomprehensive Board Review in Neurology, Second Edition, is an essential resource for neurology residents and fellows
The font and choice of colors is easy on the eyes. Is a well-written and memorable review book. The same learning style or approach to board study, few will disagree that this
This is a fantastic board review book that more than satisfactorilyĬovers the material that is tested on the ABPN exam.
0 kommentar(er)
